Scientist Organic Chemistry Bioconjugates

Scientist Organic Chemistry Bioconjugates

Location: Oss

Today, Lonza is a global leader in life sciences operating across five continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.

Lonza acquired Synaffix, a biotechnology company focused on commercializing its clinical-stage technology platform for the development of more effective and better tolerated antibody-drug conjugates (ADCs.)

In this role you will lead a team of chemists within the Bioconjugation team at Synaffix with the objective to provide linkers and payloads for customer projects and where applicable internal research purposes. General focus is on design and synthesis of cytotoxic linker-payloads for application in ADCs, however other modalities are also being pursued, including but not limited to autoimmune and targeted gene therapy. Key tasks include; planning, execution and tracking of the different projects, communicate progress with internal and external stack holders. In addition you will built a bridges with the preclinical development and small molecules teams within Lonza Visp (CH) network.  

What you’ll do:

• Manage, support and educate (Sr.) Research Associates within the Bioconjugation chemistry team, review performance, set annual objectives, agree personal development plans and provide timely constructive feedback.

• Design and execute complex multi-step synthesis routes and incorporate state-of-the-art procedures

• Active involvement in securing new customer projects whether related to GlycoConnect technology or within the broader Lonza organization

• Responsible for planning, coordination and tracking of customer focused projects and apply corrective actions where required

• Communicate with internal and external stack holders timelines, costs and progress of projects

• Ensure delivery of robust synthetic processes and good quality materials for customer projects within the agreed timelines and costs

• Delivery of project-related documentation including reports, protocols certificates of testing and where applicable tech transfer documents.

• Take assigned responsibilities in designated tasks & projects

• Adhere to company policies and quality & safety standards

• Perform other duties as assigned.

What we’re looking for:

• PhD or Msc  Bioorganic chemistry / Bioconjugation chemistry

• Expert knowledge of synthetic organic chemistry and hands-on experience working with highly potent active pharmaceutical ingredients

• Ability to analyze and characterize small molecules with laboratory techniques and equipment.

• Knowledge and hands-on experience with various automated purification techniques, and analytical techniques such as NMR, TLC, RP-HPLC, UPLC-MS

• Strong commitment to project deliverables and customer focused 

• Excellent verbal and written communication skills in English 

• Strong analytical skills (qualitative & quantitative) 

• Ability to work autonomously 

• Strong team player mentality and ability to motivate people 

• Creative and problem solving personality

• Ability to lead, motivate and support a team

Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

Lonza is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a qualified individual with disability, protected veteran status, or any other characteristic protected by law.