Research Associate

Research Associate 

Location: Oss 

The prime objective of the R&D group at Synaffix/Lonza is to provide best-in-class targeted delivery technologies, i.e. development of protein conjugation technologies, linkers and payloads. General focus is on cytotoxic ADCs, however other modalities are actively pursued, such as immuno-oncology, targeted gene therapy, neurodegenerative disease, and auto-immune disease. 

An important part of this ambition lies in the targeted delivery of drugs to a desired tissue-of-interest by means of antibody-modified vesicles (e.g. LNPs, AAVs, lentiviruses). The Research Associate will play a key role in bridging Lonza’s expertise in bioconjugations enabling the conjugation of targeting moieties to vesicles and for evaluation of vesicles with functional assays. 

What you will get: 

• An agile career and dynamic working culture. 

• An inclusive and ethical workplace. 

• Compensation programs that recognize high performance. 

• A variety of benefits dependent on role and location. 

The full list of our global benefits can be found here: https://www.lonza.com/careers/benefits.  

What you will do: 

• Executes bioconjugations with antibody (fragments) and trouble-shoots where appropriate. 

• Performs various analytical and purification techniques and can critically assess the results. 

• Evaluates formulated vesicles or antibody conjugates in functional analysis including cell-based assays (cytotoxicity, reporter cell lines) and ELISA-based assays. 

• Document results in a digital notebook environment. 

• Performs other duties as assigned. 

What we are looking for: 

• MSc degree in Biochemistry, Pharmaceutical Sciences, Biotechnology, Molecular Biology, or related field. 

• Possesses knowledge on bioconjugations and cell culture. 

• Has experience with purification techniques (ProtA, SEC, IEX) and analytical techniques (SDS-PAGE, RP-UPLC, SEC, high-resolution MS, Particle Size, Zeta Potential). 

• Has experience with cell culture techniques (transfections, functional assays, flow cytometry), and worked before with blood cells (pre). 

• Shows strong commitment to laboratory work and task delivery. 

• Communicates clearly in English verbal and in writing. 

• Acts as a strong team-player and demonstrates excellent time-management skills. 

• Has a responsible, conscientious, and sociable character.

Synaffix is a biotech company with a clinical-stage platform technology that enables best-in-class antibody-drug conjugates (ADCs), bispecific antibodies and other targeted therapeutics under a technology out-licensing business model. Synaffix was fully acquired by Lonza in June 2023. Aimed at enabling innovative medicines for patients in areas of high unmet medical need, Synaffix has forged a growing number of collaborations with top tier biotech and pharma companies by enabling best-in-class therapeutic candidates for their pipelines. 

At Lonza, our people are greatest strength. With 30+ sites across five continents, our globally connected teams work together every day to manufacture the medicines of tomorrow. Our core values of Collaboration, Accountability, Excellence, Passion and Integrity reflect who we are and how we work together. Everyone’s ideas, big or small, have the potential to improve millions of lives, and that’s the kind of work we want you to be part of. 

Innovation thrives when people from all backgrounds bring their unique perspectives to the table. At Lonza, we value diversity and are committed to creating an inclusive environment for all employees. If you’re ready to help turn our customers’ breakthrough ideas into viable therapies, we look forward to welcoming you on board. 

Ready to shape the future of life sciences? Apply now.