Manufacturing Supervisor

Manufacturing Supervisor – Cell Therapy & Mammalian Manufacturing

Location: Portsmouth, NH, USA
 

Relocation assistance available

At Lonza Portsmouth, you don’t just supervise a shift — you help lead the future of medicine.

Our site is uniquely positioned at the intersection of personalized Cell Therapy and large-scale Mammalian biologics manufacturing. In one facility, we produce both patient-specific therapies and high-volume biologic medicines that reach patients around the world. This creates a rare opportunity for manufacturing leaders to build careers that span two of the fastest-growing areas in biopharma.

We are seeking Manufacturing Supervisors to lead high-performing teams across both platforms, delivering safe, compliant, and reliable production while developing the next generation of Lonza manufacturing talent.

What You’ll Get

Leadership with Real Impact
Lead teams whose work directly supports patients — from individualized cell therapies to globally distributed biologics.

Accelerated Career Growth
Build leadership experience across multiple manufacturing modalities, positioning you for future roles in Operations, MSAT, or site leadership.

Dynamic, High-Visibility Environment
Work in both scaling cell therapy operations and world-class large-scale biologics suites.

Competitive Rewards & Benefits
Including shift differentials for night-shift leadership and full Lonza benefits:
https://www.lonza.com/careers/benefits

What You’ll Do

As a Manufacturing Supervisor, you will lead a shift of Biotechnologists / Manufacturing Associates in either Cell Therapy or Mammalian Manufacturing, with the opportunity to grow across both over time.

People & Shift Leadership

• Lead and develop a team of 6–12 associates through active coaching, feedback, and performance management
• Build engagement, accountability, and a culture of quality and safety
• Manage shift handovers, staffing plans, and daily priorities

Operational Execution

• Oversee day-to-day production in:
  • Cell Therapy: patient-specific aseptic processing, cell expansion, and cryopreservation
  • Mammalian: large-scale bioreactor operations, purification, and drug substance manufacturing
• Ensure production plans are executed safely, efficiently, and in full cGMP compliance

Quality & Compliance Leadership

• Own deviation triage, investigations, and CAPA development
• Maintain a permanent state of audit-readiness
• Serve as a frontline representative during regulatory inspections

Problem Solving & Continuous Improvement

• Lead real-time troubleshooting and escalation of technical and operational issues
• Identify bottlenecks, risks, and improvement opportunities in both mature and scaling environments
• Partner with MSAT, Engineering, and QA to support tech transfers and process improvements

Safety & 6S

• Champion proactive safety behaviors and strong 6S discipline in cleanroom and manufacturing environments

Who We’re Looking For

We are building a flexible, future-ready leadership bench.

Experience

• 3–5+ years in a cGMP manufacturing environment (Biotech, Pharma, Cell Therapy, or Biologics)
• Prior experience leading teams, shifts, or serving as a Point of Contact / Lead

Technical Foundation

• Experience in at least one of the following:
  • Aseptic processing, cell culture, or cell therapy operations
  • Mammalian cell culture, bioreactors, chromatography, or purification

Leadership Profile

• Calm and decisive under pressure
• Able to lead through change and growth
• Strong communicator who can translate technical challenges into clear action

Education

• High School Diploma or equivalent required
• Associate’s or Bachelor’s degree in Science, Engineering, or STEM preferred

Schedule

• Ability to work 12-hour rotating shifts (Day 7am–7pm or Night 7pm–7am)

Why Lonza Portsmouth

Portsmouth is one of the few sites in the industry where Advanced Therapies and Large-Scale Biologics operate side-by-side. That makes it one of the best places in biopharma to build a long-term manufacturing leadership career.

Here, you won’t just run today’s batches — you’ll help shape tomorrow’s therapies.

Lonza is proud to be an equal opportunity employer and to foster an inclusive, high-performance culture.

Ready to lead the next frontier of medicine? Apply now.